Founded in April 2013, three main themes will underpin our human immunology research programmes:
i) analysis of the interplay between adaptive and innate immune responses to optimize vaccination strategies;
ii) the role of the local micro-environment in modulating innate and adaptive immune responses;
iii) understanding the mechanisms which control resolution of inflammatory processes during infectious diseases and cancer.
Understanding the effects of inflammation on the ability of the adaptive immune system to mount effective antigen specific responses has broad implications in Immunology and in particular to the development of diagnostics and therapeutics in the field of cancer immunity and chronic viral infections.
These three objectives will be underpinned by the development of a joint translational programme, to carry out hypothesis driven clinical trials based on a close collaboration between clinicians and basic scientists to improve cancer treatment, and the treatment of chronic viral infections. To discover, qualify and validate biomarkers predicting treatment response and to explore how these can be utilised in prospective biomarker driven clinical trials.